p53; Clone DO-1 (Ready-To-Use)
Species: Mouse Monoclonal
Clone: DO-1
Isotype: IgG2a
MW: 53 kD
Species Reactivity: Human, Monkey, Cow, and weak reaction with Mouse and Rat.
Positive Control: About 50% of breast carcinomas are positive for p53, especially those lacking estrogen and/or progesterone receptor, or with high proliferation index.
Specificity: Recognizes a 53kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with mutant as well as wild form of p53. Its epitope maps within the N-terminus (aa37-45) of p53. Monoclonal antibody Pab 1801 does not block the binding of DO-1 to p53 in an ELISA test.