GMS Stain Kit with Periodic Acid
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Product Information
The Modified Gomori Methenamine-Silver Nitrate Stain (GMS Stain Kit) is intended for use in the histologic visualization of fungi, basement membrane and some opportunistic organisms such as Pneumocystis carinii. Periodic acid replaces traditional chromic acid as a less hazardous oxidation alternative. Background connective tissue may stain blacker in comparison with standard chromic acid oxidation.
Fungi: Black
P. carinii: Black
Mucin: Gray
Mycelia (inner): Gray to Black
Hyphae (inner): Gray to Black
Background: Light Green
Literary References
McManus, J.F.A. and Mowry, R. 1955. Staining Methods and Histologic and Histochemical. Grocott, pp 194-197.
Sale, G.E. 1978. Rapid Methenamine Silver Stain. Arch Path Lab Med, 1978, 102, pp 351-352.
Sheehan, D.C., Hrapchak, B.B. 1980. Theory and Practice of Histotechnology, 2nd edition, CV Mosby Company, St. Louis, MO.
Koski, J.P. 1981. Silver methenamine-borate (SMB); Cost reduction with technical improvement in silver nitrate-gold chloride impregnation’s. Journal of Histotechnology 4:115.
Raab, S.S. et al. 1994. Utility of Gomori methenamine silver stains in bronchoalveolar lavage specimens. Modern Pathology, June 1994, Vol. 7, No. 5, pp 599-604.
Procop, G.W. et al. 2004. Detection of Pneumocystis jiroveci in Respiratory Specimens by Four Staining Methods. Journal of Clinical Microbiology. July 2004, Vol. 42, No. 7, pp 3333-3335.
Bryan, R.A., Jiang, Z., Howell, R.C., Morgenstern, A., Bruchertseifer, F., Casadevall, A., Dadachova, E. Radioimmunotherapy is More Effective than Antifungal Treatment in Experimental Cryptococcal Infection. Journal of Infectious Disease, August 15, 2010. Vol. 202(4): pages 633-637.
Freida L. Carson, Jerry Fredenburgh & John E. Maxwell (1999) Inconsistent Detection of Histoplasma capsulatum with Periodic Acid Oxidation in the Grocott Methenamine-Silver Nitrate (GMS) Fungus Stain, Journal of Histotechnology, 22:2, 119-122, DOI: 10.1179/his.1999.22.2.119
Resources
Instructions For Use
Material Safety Data Sheets
