Epithelial Membrane Antigen; Clone E29
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Product Information
Species: Mouse
Immunogen: Delipidated extract of human milk fat globule membranes
Clone: E29
Isotype: IgG2a, kappa
Species Reactivity: Human. Reacts moderately with Pig and Dog. Others not known.
Positive Control: MCF-7 or MDA-231 cells. Breast or colon carcinoma.
Specificity: In Western blotting, this antibody recognizes proteins in a MW range of 265-400kDa, identified as different glycoforms of MUC1. This antibody reacts with the DTRP epitope within the tandem repeats. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. An antibody to MUC1 is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.
Literary References
Majumdar K, Tyagi I, Saran RK, Sakhuja P, Sharma A. Medulloblastoma with focal divergent/teratoid differentiation. Brain tumor pathology. 2013 Jan;30(1):50-6.
Carvounis EE, Smyrniotis V, Chatziioannou A, Paphitis A. Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas. International journal of gastrointestinal cancer. 2003 Jun;33(2):103-6.
