Actin, Muscle Specific; Clone HHF35
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Product Information
Species: Mouse
Immunogen: SDS extract of human myocardium.
Clone: HHF35
Isotype: IgG1, Kappa
Species Reactivity: Human, Rabbit, Cat, Dog, Mouse, Rat, Chicken. Others-not known
Positive Control: Muscle or sarcoma
Specificity: This antibody reacts with actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. This antibody recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative. In addition, it stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).
Literary References
Kojima M, Nakamura S, Itoh H, Suchi T, Masawa N. Inflammatory pseudotumor of the submandibular gland: report of a case presenting with autoimmune disease-like clinical manifestations. Archives of pathology & laboratory medicine. 2001 Aug;125(8):1095-7.
Koide O, Matsuzaka K, Tanaka Y. Multiple giant angiomyolipomas with a polygonal epithelioid cell component in tuberous sclerosis: an autopsy case report. Pathology international. 1998 Dec;48(12):998-1002.
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